Symptoms include mental status changes such as agitation, hallucinations, coma, or delirium a fast heart rate dizziness flushing muscle tremor or rigidity and stomach symptoms (including nausea, vomiting, and diarrhea). Interaction or overdosage may also cause serotonin syndrome.Codeine may interact with several drugs, including those that affect hepatic enzymes CYP 3A4 or CYP 2D6, and those that also cause respiratory depression (such as other opioids, benzodiazepines, and alcohol).Not for use in children under the age of 18. The risk is greater with higher dosages of codeine, in people with pre-existing respiratory disease, in seniors or the frail, or in those taking other medications that cause respiratory depression (such as benzodiazepines). Rarely, serious, life-threatening, breathing problems may occur attributable to the codeine component.Consider alternative analgesics if codeine is not having the desired pain-relieving effect. Marked differences may exist in the analgesic effect provided by codeine due to genetic variations in the CYP 2D6 liver enzyme responsible for metabolizing codeine into morphine.Babies born to mothers who are physically dependent on codeine will also be physically dependent. Abrupt discontinuation of codeine in a person who has become physically dependent on it may lead to a withdrawal syndrome and symptoms such as restlessness, pupil dilation, watery eyes and a runny nose, sweating, muscle aches, insomnia, irritability, and gastrointestinal complaints.Legitimate supplies of products containing codeine may be sought out by drug seekers. Tolerance can also develop to codeine's analgesic effect (this means that the same dose does not provide as much pain relief as before). Codeine should only be used short-term at the lowest effective dose and only when other nonopioid analgesics are not effective. Codeine is addictive (habit-forming) and potentially abusable.Codeine may also affect blood pressure, manifesting as dizziness when standing and stimulate histamine release, which may cause symptoms such as flushing, itchiness, sweating, or red eyes.This can lead to symptoms such as nausea, vomiting, constipation, and abdominal pain. Codeine also slows down the motility of the gastrointestinal tract. Drowsiness or dizziness which may impair reaction skills and affect a person's ability to drive or operate machinery.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: May be used to treat mild-to-moderate pain that is unrelieved by nonopioid analgesics.Codeine may also be called a narcotic analgesic.
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